The American international left the first leg game of the round of 16 of the Champions League with an injury; he'll miss the next two Bundesliga matches with Dortmund.
Pulisic will miss besides the games against Nuremberg the one against Bayer Leverkusen, a big blow to Dortmund who will also be without captain Marco Reus.
Pulisic will move to the Premier League with Chelsea in the summer after completing a 73.1 million dollar transfer fee in January.
The American managed to play for 88 minutes at Wembley Stadium and has been enduring a frustrating season with the German team, making only 13 league appearances, scoring one goal with two assists with just five games as a starter.
Dortmund will host Tottenham for the second leg game of the round of 16 of the Champions League on March 5.